Lyophilizer Loading / Unloading
Present
technologies in use to load and unload vials in a lyophilizer, can vary
from manual to completely automated. Manual loading is typical of a lab
or pilot plant lyophilizer units where the quantity of vials are smaller
and easier to handle. Trays of vials would be placed on the shelves, one
at a time, and pushed into position loading from back to the front of
each shelf. This would require tools to be able to push and retrieve the
trays during loading and unloading. The loading and unloading areas of
the Lyophilizer must also be in a laminar flow Class 100 area.
However, manually
loading larger pilot scale to production sized units, the lyophilizer
loading and unloading of thousands of glass vials would become much more
time consuming, strenuous, and typically utilizes some additional
equipment such as accumulator tables, tray loaders for arranging vials
onto a tray which will assist the operator in properly configuring vials
into trays and
manual loading and unloading them. Vial positioning on trays can be
crucial to some Lyophilization processes and tray loaders provide a
repeatable vial orientation on the trays for each vial size used.
Whether vials trays are bottomless or have bottoms or are constructed of
stainless steel or plastic, is a process related issue and should be
evaluated from a material handling concern as well as a heat transfer
concern. Plastic trays do not significantly
impede heat
transfer between the cooled shelves and the glass vial; however, they
are flimsy and may not be able to firmly support some of the larger vial
sizes satisfactorily.
Bottomless vial
trays are best for processing product contained in vials as they allow
for the vials to sit directly on the shelf, for the most efficient heat
transfer between shelf and product. The trend in processing liquid
products in vials is towards use of the bottomless trays or fences, as
they are also referred to as. Fences sit on the shoulder of the vials
and keep the vials in a tight
pack for sliding
onto and off of the chamber shelves. The type of tray to be used should
be evaluated along with other scaleup considerations when developing the
process.
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